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Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents

Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents

Scoutaris, Nicolaos, Malamatari, Maria, Letellier, Adrien and Douroumis, Dennis (2017) Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents. Drug Delivery and Translational Research, 8 (1). pp. 32-42. ISSN 2190-393X (Print), 2190-3948 (Online) (doi:10.1007/s13346-017-0430-3)

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Abstract

Three-layer thin films comprising of two polymers as substrate (ethyl cellulose and, copovidone K28) and three antihypertensive agents (hydrochlorothiazide, amiloride HCl, and carvedilol) were printed using jet dispensing technology. Two film formulations with different ethyl cellulose to copovidone K28 ratio (i.e., 90/10 and 50/50 w/w) were prepared using a three-course dispensing. The films were characterized regarding surface morphology, solid-state properties, polymer-drug interactions, drug distribution in each layer, and in vitro drug release. All the components of the films were found to be in the amorphous state apart from hydrochlorothiazide which retained its crystallinity. FT-IR spectroscopy revealed hydrogen bond interactions between carvedilol and copovidone K28. Combinations of ethyl cellulose and copovidone K28 provide suitable polymeric film substrates with the ability to modify drug release. Particularly, decreased ethyl cellulose to copovidone K28 weight ratio was found to suppress the crystallization of hydrochlorothiazide and to increase the release rate of the dispensed drugs. Jet dispensing was found to be a rapid technology for the preparation of multi-layered films that can be used as personalized formulations for the delivery of combinations of drugs.

Item Type: Article
Uncontrolled Keywords: Jet dispensing; Films; Combination therapy; Antihypertensive drugs
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 05 Apr 2018 13:42
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/18415

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