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Composite alginate-hyaluronan sponges for the delivery of tranexamic acid in post-extractive alveolar wounds

Composite alginate-hyaluronan sponges for the delivery of tranexamic acid in post-extractive alveolar wounds

Boateng, Joshua (2017) Composite alginate-hyaluronan sponges for the delivery of tranexamic acid in post-extractive alveolar wounds. Journal of Pharmaceutical Sciences. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1016/j.xphs.2017.09.026)

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Abstract

The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a non-satisfactory healing process. Here we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding by occluding the post-extractive alveolar wounds, and simultaneously, capable of a fast release of tranexamic acid (TA). Composite alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a straightforward internal gelation method followed by a freeze-drying step. Both blank and drug-loaded sponges were soft, flexible, elegant in appearance and non-brittle in nature. SEM analysis confirmed the porous nature of these dressings. The integration of HA influenced the microstructure, reducing the porosity, modifying the water uptake kinetic and increasing the resistance to compression. TA release from ALG/HA sponges showed a controlled release up to 3h and it was faster in the presence of HA. Finally, an in vitro clotting test performed on human whole blood confirmed that the TA-loaded sponges significantly reduce the blood clotting index (BCI) by 30% compared to ALG/HA20 sponges. These results suggest that, if placed in a socket cavity, these dressings could give a relevant help to the blood hemostasis after dental extractions, especially in patients with coagulation disorders.

Item Type: Article
Uncontrolled Keywords: Alginate, Biodegradable polymers, Controlled delivery, Wound healing, Mechanical properties
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 06 Nov 2017 14:58
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/17764

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