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Drug delivery innovations to address global health challenges for pediatric and geriatric populations (through improvements in patient compliance)

Drug delivery innovations to address global health challenges for pediatric and geriatric populations (through improvements in patient compliance)

Boateng, Joshua (2017) Drug delivery innovations to address global health challenges for pediatric and geriatric populations (through improvements in patient compliance). Journal of Pharmaceutical Sciences, 106 (11). pp. 3188-3198. ISSN 0022-3549 (Print), 1520-6017 (Online) (doi:10.1016/j.xphs.2017.07.009)

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Abstract

Despite significant advances in pharmaceutical and biotechnological drug discovery, the global population is plagued with many challenging diseases. These are further compounded by anticipated explosion in an ageing population, which presents several problems such as polypharmacy, dysphagia, and neurologic conditions, resulting in noncompliance and disease complications. For antibiotics, poor compliance, can result in development of drug-resistant infections which can be fatal. Furthermore, children, especially, in developing countries die unnecessarily from easily treatable diseases (e.g., malaria), due to poor compliance arising from bitter taste and inability to swallow currently available medication. Although some of these challenges require the discovery of new drug compounds, a significant number can be resolved by employing pharmaceutics approaches to reduce the incidence of poor patient compliance. Such solutions are expected to make swallowing easier and reduce the need to swallow several solid medications, which is difficult for vulnerable pediatric and geriatric patients. This commentary will explore the current state of the art in the use of drug delivery innovations to overcome some of these challenges, taking cues from relevant regulatory agencies such as the Food and Drug Administration, the European Medicines Agency, World Health Organization, and the peer-reviewed scientific and clinical literature.

Item Type: Article
Uncontrolled Keywords: Buccal, Geriatric; Global health challenges; Malaria; Mucosal drug delivery; Patient compliance; Pediatric; Personalized medicine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 06 Nov 2017 17:04
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/17654

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