Powell, Alison, Caterson, Bruce, Hughes, Clare, Paul, Alison, James, Craig, Hopkins, Stephen, Mansour, Omar and Griffiths, Peter ORCID: 0000-0002-6686-1271 (2017) Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route? Journal of Drug Targeting. pp. 1-22. ISSN 1061-186X (Print), 1029-2330 (Online) (doi:https://doi.org/10.1080/1061186X.2017.1378660)

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Abstract

The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy, and is defined to a large part by the many and complex cellular biological and biochemical barriers such a construct must traverse. It is shown here that model dextrin conjugates are able to pass through a cartilaginous extracellular matrix into chondrocytes, with little perturbation of the matrix structure, indicating that targeting of potential therapeutics through a cartilaginous extracellular matrix should prove possible. Rapid chondrocytic targeting of drugs which require intracellularisation for their activity, and uniform extracellular concentrations of drugs with an extracellular target, is thus enabled though polymer conjugation.

Item Type:	Article
Uncontrolled Keywords:	Scattering, Diffusion, NMR
Subjects:	Q Science > QC Physics Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Materials & Analysis Research Group
Last Modified:	12 Sep 2018 00:38
URI:	http://gala.gre.ac.uk/id/eprint/17632

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