Skip navigation

Effects of crystal habit on the sticking propensity of ibuprofen — A case study

Effects of crystal habit on the sticking propensity of ibuprofen — A case study

Hooper, D., Clarke, F. C., Docherty, R., Mitchell, J. C. ORCID: 0000-0003-2945-3292 and Snowden, M. J. (2017) Effects of crystal habit on the sticking propensity of ibuprofen — A case study. International Journal of Pharmaceutics, 531 (1). pp. 266-275. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2017.08.091)

[img]
Preview
PDF (Author Accepted Manuscript)
17581 MITCHELL_Effects_of_Crystal Habit_2017.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview

Abstract

This study demonstrates the effect of active pharmaceutical ingredient (API) particle habit on the sticking propensity of ibuprofen. Four diverse crystal habits with similar physico chemical properties are reported and the sticking propensity was found to increase with shape regularity. The surface energy of the extreme habits were shown to be different where particles that were more regular in shape exhibited surface energies of 9 mJ/m2 higher than those that were needle-like in habit. Computational and experimental data reveals that the increase in surface energy of the regular shaped particles can be attributed to the increase in the specific (polar) component, which is due to greater presence of faces which contain the carboxylic acid functionality at the surface. The increase in the specific energy component is shown to correlate with the sticking propensity of ibuprofen. It is proposed that investigation of the chemical causality of sticking, for this API and others, using the techniques demonstrated in this paper will be of increasing importance

Item Type: Article
Uncontrolled Keywords: Particle shape; Surface energy; Punch sticking; Crystal chemistry
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 25 Aug 2018 00:38
Selected for GREAT 2016: None
Selected for GREAT 2017: GREAT c
Selected for GREAT 2018: GREAT a
URI: http://gala.gre.ac.uk/id/eprint/17581

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics