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Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients

Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients

Maniruzzaman, M., Ross, S.A., Islam, M.T, Scoutaris, N., Nair, A. and Douroumis, Dennis (2017) Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy, 43 (6). pp. 947-957. ISSN 0363-9045 (Print), 1520-5762 (Online) (doi:10.1080/03639045.2017.1287716)

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Abstract

The purpose of this study was to evaluate the performance of Neusilin® (NEU) a synthetic magnesium aluminometasilicate as inorganic drug carrier co-processed with the hydrophilic surfactants Labrasol and Labrafil to develop Tranilast (TLT) based solid dispersions using continuous melt extrusion (HME) processing. Twin – screw extrusion was optimized to develop various TLT/excipient/surfactant formulations followed by continuous capsule filling in the absence of any downstream equipment. Physicochemical characterisation showed the existence of TLT in partially crystalline state in the porous network of inorganic NEU for all extruded formulations. Furthermore, the in line NIR studies revealed a possible intermolecular H–bonding formation between the drug and carrier resulting in the increase of dissolution of TLT. The capsules containing TLT extruded solid dispersions showed enhanced dissolution rates and compared with the marketed Rizaben® product.

Item Type: Article
Uncontrolled Keywords: Extrusion; Solid dispersions; Excipients; Drug – excipient interactions dissolution.
Subjects: R Medicine > R Medicine (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Centre for Innovation and Process Engineering in Research (CIPER)
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 21 Feb 2018 01:38
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/16253

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