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Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules.

Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules.

Boateng, J.S. ORCID: 0000-0002-6310-729X and Areago, D. (2014) Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules. Austin Journal of Analytical and Pharmaceutical Chemistry, 1 (5):1022. pp. 1-7. ISSN 2381-8913 (Online)

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Abstract

The objective of this study was to develop a composite buccal wafer for protein drug delivery. The polymeric vehicle used in this study combined chitosan and sodium alginate with bovine serum albumin (BSA) as a model drug. The wafers were obtained by freeze-drying gels of the polymers in well plates. Prior to the lyophilisation process, differential scanning calorimetry was performed to establish a suitable freeze-drying cycle. Preliminary characterization experiments were undertaken to select the optimum composite gel containing sodium alginate and chitosan in a 4:1 ratio respectively for drug loading. A second series of characterisation tests were performed on the drugloaded wafers prepared from gels containing 0.25 and 0.5 % w/w of BSA. The formulations were functionally characterised for swelling, mucoadhesive and drug dissolution properties. The morphology and crystallinity were investigated using a scanning electron microscope and X-ray diffractometer respectively. The results from drug dissolution studies over a two-hour period showed 66% and 31% cumulative drug release for the wafers obtained from gels containing 0.25 and 0.50 % w/w BSA respectively. These results show the feasibility of developing a sustained delivery system for macromolecules by combining chitosan and sodium alginate.

Item Type: Article
Additional Information: Boateng et al. © All rights are reserved. Austin Journal of Analytical and Pharmaceutical Chemistry is an international, open access, peer review Journal publishing original research & review articles in all the related fields of Analytical and Pharmaceutical Chemistry.
Uncontrolled Keywords: Chitosan; Sodium alginate; Bovine serum albumin; Buccal delivery; Protein delivery
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 05 Dec 2016 17:26
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/16071

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