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Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules.

Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules.

Boateng, J.S. and Areago, D. (2014) Composite sodium alginate and chitosan based wafers for buccal delivery of macromolecules. Austin Journal of Analytical and Pharmaceutical Chemistry, 1 (5):1022. pp. 1-7. ISSN 2381-8913 (Online)

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Abstract

The objective of this study was to develop a composite buccal wafer for protein drug delivery. The polymeric vehicle used in this study combined chitosan and sodium alginate with bovine serum albumin (BSA) as a model drug. The wafers were obtained by freeze-drying gels of the polymers in well plates. Prior to the lyophilisation process, differential scanning calorimetry was performed to establish a suitable freeze-drying cycle. Preliminary characterization experiments were undertaken to select the optimum composite gel containing sodium alginate and chitosan in a 4:1 ratio respectively for drug loading. A second series of characterisation tests were performed on the drugloaded wafers prepared from gels containing 0.25 and 0.5 % w/w of BSA. The formulations were functionally characterised for swelling, mucoadhesive and drug dissolution properties. The morphology and crystallinity were investigated using a scanning electron microscope and X-ray diffractometer respectively. The results from drug dissolution studies over a two-hour period showed 66% and 31% cumulative drug release for the wafers obtained from gels containing 0.25 and 0.50 % w/w BSA respectively. These results show the feasibility of developing a sustained delivery system for macromolecules by combining chitosan and sodium alginate.

Item Type: Article
Additional Information: Boateng et al. © All rights are reserved. Austin Journal of Analytical and Pharmaceutical Chemistry is an international, open access, peer review Journal publishing original research & review articles in all the related fields of Analytical and Pharmaceutical Chemistry.
Uncontrolled Keywords: Chitosan; Sodium alginate; Bovine serum albumin; Buccal delivery; Protein delivery
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 05 Dec 2016 17:26
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/16071

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