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Analysis of naturally occurring steroid hormones in infant formulas by HPLC-MS/MS and contribution to dietary intake

Analysis of naturally occurring steroid hormones in infant formulas by HPLC-MS/MS and contribution to dietary intake

Barreiro, Rocío, Regal, Patricia, Díaz-Bao, Mónica, Fente, Cristina and Cepeda, Alberto (2015) Analysis of naturally occurring steroid hormones in infant formulas by HPLC-MS/MS and contribution to dietary intake. Foods, 4 (4). pp. 605-621. ISSN 2304-8158 (Print), 2304-8158 (Online) (doi:10.3390/foods4040605)

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Abstract

Milk is a natural fluid and as such contains small amounts of naturally occurring steroids. Human milk is recommended as the optimal source of nutrients for infants and young children, and it has been associated to several short- and long-term benefits. For this reason, its composition is used as a reference for designing infant formulas. However, the available information on the hormonal levels of these dairy products is scarce, and it is usually limited to estradiol and estrone. In the present study, six natural sex hormones (pregnenolone, progesterone, estrone, dehydroepiandrosterone, testosterone and androstenedione) have been extracted from sixteen milk-based infant formulas and analyzed with liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The purpose of this research was to quantify natural steroid hormones in various infant formulas, to provide food and nutrition practitioners with information to estimate intakes in children. In addition, data found in the literature was used for comparison. The findings suggest that there are certain similarities between bovine milk and dairy products for infants. Furthermore, the detected levels were in general lower than those observed in human milk and/or colostrum. The reported results represent a valuable addition to the current knowledge on natural hormone content of infant foods.

Item Type: Article
Additional Information: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).
Uncontrolled Keywords: infant formula; steroid hormone; estrogen; progestogen; androgen; breast milk; bovine milk; daily intake; LC-MS/MS
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:14
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/15754

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