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Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy

Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy

Boateng, Joshua S. ORCID: 0000-0002-6310-729X and Okeke, Obinna C. (2016) Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy. Carbohydrate Polymers, 155. pp. 78-88. ISSN 0144-8617 (doi:10.1016/j.carbpol.2016.08.053)

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Abstract

Composite wafers and films comprising HPMC and sodium alginate (SA) were formulated for nicotine (NIC) replacement therapy via the buccal route. Magnesium aluminium silicate (MAS) was added in different concentration ratios (0.25, 0.5, 0.75) to stabilize NIC and its effect on mechanical properties, internal and surface morphology, physical form, thermal properties, swelling, mucoadhesion, drug content and release behaviour of the formulations was investigated. MAS changed the physico-mechanical properties of the composite formulations causing a decrease in mechanical hardness, collapsed wafer pores, increased roughness of film surface, increase in crystallinity and decreased mucoadhesion of the wafers. However, MAS increased swelling in both films and wafers as well as interaction between NIC and SA, which increased drug-loading capacity. Further, MAS resulted in rapid and slow release of NIC from wafers and films respectively. The results suggest that the ideal formulation for the stabilization of NIC in the composite formulations was MAS 0.25.

Item Type: Article
Additional Information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Buccal delivery; Magnesium Aluminium Silicate (MAS); Nicotine; Nicotine replacement therapy; Sodium alginate
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 22 Aug 2017 14:49
Selected for GREAT 2016: None
Selected for GREAT 2017: GREAT a
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/15720

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