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Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs

Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs

Casal-Dujat, Lucía, Griffiths, Peter C., Rodríguez-Abreu, Carlos, Solans, Conxita, Rogers, Sarah and Pérez-García, Lluïsa (2013) Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs. Journal of Materials Chemistry B, 1 (38). pp. 4963-4971. ISSN 2050-750X (doi:10.1039/C3TB20289E)

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Abstract

Dicationic gemini surfactants based on bis-imidazolium salts with bromide counterions were synthesized and shown to self-assemble into micellar-type structures in aqueous solution. The solubilisation capability of these micelles for anionic drugs (valproate) indicates their great potential as drug nanocarriers. A range of physicochemical techniques including surface tension, fluorescence spectroscopy, small-angle neutron scattering (SANS) and pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) have been used to determine the nanocarrier (micelle) structure and to quantify the interaction of the drug with the nanocarrier. The insights gained here, structural activity relationships such as hydrophobic dependence of the CMC and drug binding isotherms, will allow for a rational optimization of molecular structure.

Item Type: Article
Uncontrolled Keywords: micelles, scattering, NMR
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 17 Oct 2016 09:14
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/15713

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