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The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine

The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine

Raeburn, Jaclyn, Mendoza-Cuenca, Cristina, Cattoz, Beatrice N., Little, Marc A., Terry, Ann E., Zamith Cardoso, Andre, Griffiths, Peter C. and Adams, Dave J. (2014) The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine. Soft Matter, 11 (5). pp. 927-935. ISSN 1744-683X (Print), 1744-6848 (Online) (doi:10.1039/C4SM02256D)

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Abstract

Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.

Item Type: Article
Additional Information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Uncontrolled Keywords: hydrogels, scattering
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 17 Oct 2016 09:14
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/15712

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