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Emerging pollutants and plants – Metabolic activation of diclofenac by peroxidases

Emerging pollutants and plants – Metabolic activation of diclofenac by peroxidases

Huber, Christian, Preis, Martina, Harvey, Patricia J. ORCID: 0000-0001-7193-4570, Grosse, Sylvia, Letzel, Thomas and Schröder, Peter (2016) Emerging pollutants and plants – Metabolic activation of diclofenac by peroxidases. Chemosphere, 146. pp. 435-441. ISSN 0045-6535 (Print), 1879-1298 (Online) (doi:10.1016/j.chemosphere.2015.12.059)

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Abstract

Human pharmaceuticals and their residues are constantly detected in our waterbodies, due to poor elimination rates, even in the most advanced waste water treatment plants. Their impact on the environment and human health still remains unclear. When phytoremediation is applied to aid water treatment, plants may transform and degrade xenobiotic contaminants through phase I and phase II metabolism to more water soluble and less toxic intermediates. In this context, peroxidases play a major role in activating compounds during phase I via oxidation. In the present work, the ability of a plant peroxidase to oxidize the human painkiller diclofenac was confirmed using stopped flow spectroscopy in combination with LC-MS analysis. Analysis of an orange colored product revealed the structure of the highly reactive Diclofenac-2,5-Iminoquinone, which may be the precursor of several biological conjugates and breakdown products in plant

Item Type: Article
Uncontrolled Keywords: Diclofenac, Iminoquinone, Peroxidase, Stopped flow spectroscopy, LC-MS
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 13 Jul 2017 13:47
Selected for GREAT 2016: None
Selected for GREAT 2017: GREAT b
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/14646

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