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Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos

Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos

Rahman, Aziz M., Hwang, Gyulin, Müller, Ferenc, Williams, Darren W., Murdock, Paul J., Pasi, K. John, Goldspink, Geoffrey, Farahmand, Hamid and Maclean, Norman (2004) Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos. Marine Biotechnology, 6 (5). pp. 485-492. ISSN 1436-2228 (Print), 1436-2236 (Online) (doi:10.1007/s10126-004-3121-2)

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Abstract

A plasmid containing human coagulation factor VII (hFVII) complementary DNA regulated by a cytomegalovirus promoter was microinjected into fertilized eggs of zebrafish, African catfish, and tilapia. The active form of hFVll was detected in the fish embryos by various assays. This positive expression of human therapeutic protein in fish embryos demonstrates the possibility of exploitation of transgenic fish as bioreactors.

Item Type: Article
Uncontrolled Keywords: human coagulation factor VII, transgenic fish, bioreactor.
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 17 Oct 2016 09:14
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/14498

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