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Bioactivity, biocompatibility and antimicrobial properties of a chitosan-mineral composite for periodontal tissue regeneration

Bioactivity, biocompatibility and antimicrobial properties of a chitosan-mineral composite for periodontal tissue regeneration

Hurt, Andrew P., Kotha, Arun K., Trivedi, Vivek and Coleman, Nichola (2015) Bioactivity, biocompatibility and antimicrobial properties of a chitosan-mineral composite for periodontal tissue regeneration. Polimeros, 25 (3). pp. 311-316. ISSN 0104-1428 (Print), 1678-5169 (Online) (doi:10.1590/0104-1428.1835)

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Abstract

A composite membrane of the polymer, chitosan, and the silver-exchanged mineral phase, tobermorite, was prepared by solvent casting and characterised by scanning electron microscopy and Fourier transform infrared spectroscopy. The in vitro bioactivity, cytocompatibility and antimicrobial activity of the composite were evaluated with respect to its potential application as a guided tissue regeneration (GTR) membrane. The in vitro bioactivity was verified by the formation of hydroxyapatite on the surface of the membrane in simulated body fluid and its cytocompatibility was established using MG63 human osteosarcoma cells. The presence of silver ions conferred significant antimicrobial activity against S. aureus, P. aeruginosa and E. coli. The findings of this investigation have indicated that the chitosansilver-tobermorite composite is a prospective candidate for GTR applications.

Item Type: Article
Additional Information: "All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License" <http://www.scielo.br/scielo.php?script=sci_serial&pid=0104-1428&lng=en&nrm=iso>
Uncontrolled Keywords: Chitosan, Tobermorite, Silver, Bioactive, Antimicrobial, guided tissue regeneration, Periodontal repair
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 04 Dec 2017 10:32
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/14486

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