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Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy

Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy

Ehiwe, Tracy O., Alexander, Bruce D, Mitchell, John C. ORCID: 0000-0003-2945-3292, Snowden, Martin J. and Waters, Laura J. (2016) Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy. Journal of Pharmaceutical Analysis, 6 (3). ISSN 2095-1779 (Print), 2214-0883 (Online) (doi:10.1016/j.jpha.2015.12.002)

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Abstract

This study investigated the development of a novel approach to surface characterisation of drug polymorphism and the extension of the capabilities of this method to perform ‘real time’ in situ measurements. This was achieved using diffuse reflectance visible spectroscopy (DRV spectroscopy) and dye deposition, using the pH sensitive dye, thymol blue (TB). Two polymorphs, SFN-β and SFN-γ, of the drug substance sulfanilamide (SFN) were examined. The interaction of adsorbed dye with polymorphs showed different behavior, and thus reported different DRV spectra. Consideration of the acid/base properties of the morphological forms of the drug molecule provided a rationalization of the mechanism of differential coloration by indicator dyes. The kinetics of the polymorphic transformation of sulfanilamide polymorphs was monitored using treatment with TB dye and DRV spectroscopy. The thermally-induced transformation fitted a first-order solid-state kinetic model (R2 = 0.992), giving a rate constant of 2.43 x 10−2 s−1.

Item Type: Article
Additional Information: This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
Uncontrolled Keywords: Polymorphic transformation; Sulfanilamide; Diffuse reflectance visible spectroscopy; Powder X-ray diffraction; Differential scanning Calorimetry
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Medway Centre for Pharmaceutical Science
Last Modified: 18 Apr 2017 14:58
Selected for GREAT 2016: None
Selected for GREAT 2017: GREAT a
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/14218

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