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Taste masked thin films printed by jet dispensing

Taste masked thin films printed by jet dispensing

Scoutaris, Nikolaos, Snowden, Martin and Douroumis, Dennis (2015) Taste masked thin films printed by jet dispensing. International Journal of Pharmaceutics, 494 (2). pp. 619-622. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2015.05.018)

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Abstract

Taste masking of bitter active substances is an emerging area in the pharmaceutical industry especially for paediatric/geriatric medications. In this study we introduce the use of jet – dispensing as a taste masking technology by printing mucosal thin films of three model bitter substances, Cetirizine HCl, Diphenylhydramine HCl and Ibuprofen. The process was used to dispense aqueous drugs/polymer solutions at very high speed where eventually the drugs were embedded in the polymer matrix. The in vivo evaluation of jet – dispensed mucosal films showed excellent taste masking for drug loadings from 20 - 40%. Jet dispensing was proved to make uniform, accurate and reproducible thin films with excellent content uniformity.

Item Type: Article
Uncontrolled Keywords: jet dispensing, printing, taste masking, water insoluble drugs
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 04 Dec 2017 11:19
Selected for GREAT 2016: GREAT b
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/13488

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