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Antihyperlipidemic components of Cassia auriculata aerial parts: Identification through in vitro studies.

Antihyperlipidemic components of Cassia auriculata aerial parts: Identification through in vitro studies.

Habtemariam, Solomon (2013) Antihyperlipidemic components of Cassia auriculata aerial parts: Identification through in vitro studies. Phytotherapy Research, 27 (1). pp. 152-155. ISSN 0951-418X (Print), 1099-1573 (Online) (doi:10.1002/ptr.4711)

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Abstract

Cassia auriculata (Caesalpiniaceae) is a common Asian beverage and medicinal plant widely used in tradition medicine for diabetes, hyperlipidemia and various other disease conditions. Previous studies on crude extracts of C. auriculata have documented the scientific basis for some of its traditional medicinal uses. The present study investigates the antilipase activity of the ethanol extract of the aerial parts along with the previously isolated compounds (kaempferol-3-O-rutinoside, rutin, kaempferol, quercetin and luteolin). The crude extract displayed inhibitory activity against pancreatic lipase with IC50 of 6.0 ± 1.0 µg/mL. The most active antilipase compound was kaempferol-3-O-rutinoside with IC50 value (2.9 ± 0.50 μM) only about twice weaker than the standard antilipase drug, orlistat (IC50 = 1.45 ± 0.26 μM). Luteolin, quercetin and rutin were found to be weak pancreatic lipase inhibitors (IC50 over 100 μM), whereas kaempferol showed no activity up to 250 μM. The antihyperlipidemic effect of C. auriculata could be attributed to direct lipase inhibitory effect of the plant constituents

Item Type: Article
Uncontrolled Keywords: Cassia auriculata, Caesalpiniaceae, Antilipase, Kaemperol-3-O-rutinoside rutin, Quercetin, luteolin, Kaempferol
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/13435

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