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Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin

Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin

Cockram, James, Hill, Colin, Burns, Corrinne, Arroo, Randoph R. J., Woolley, Jack G., Flockart, Ian, Robinson, Trevor, Atkinson, Christopher J., Davies, Michael J., Dungey, Nigel, Greenland, Andy J., Smith, Lydia L. M. J. and Bentley, Steven (2012) Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin. Plant Genetic Resources, 10 (02). pp. 152-154. ISSN 1479-2621 (Print), 1479-263X (Online) (doi:10.1017/S1479262112000159)

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Abstract

The anti-malarial drug artemisinin is commercially extracted from the medicinal plant Artemisia annua (L.). Here we report the screening of seventy A. annua individuals sourced from around the world, identifying individuals containing > 2% artemisinin, concentrations approximately twice as high as have been previously reported. These extremely high yielding individuals have been maintained as propagational clones, and represent promising parental lines for future A. annua breeding programmes.

Item Type: Article
Additional Information: [1] Acknowledgement (funding): The present work was funded by Defra through the Renewable Materials LINK Programme (LK0822: 'Developing an alternative UK industrial crop Artemisia annua, for the extraction of Artemisinin to treat multi-drug resistant malaria'), with financial input from the Horticultural Development Company and NIAB Trust. [2] Copyright: © NIAB 2012
Uncontrolled Keywords: chemovar, plant pre-breeding, Plasmodium falciparum, Molecular Targets and Activities
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QK Botany
S Agriculture > SB Plant culture
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Natural Resources Institute
Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Related URLs:
Last Modified: 29 Jul 2015 17:52
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12793

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