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Physico-chemical characterization of oral thin film for paediatric buccal drug delivery

Physico-chemical characterization of oral thin film for paediatric buccal drug delivery

Khan, S., Boateng, J.S. ORCID: 0000-0002-6310-729X, Okeke, O., Trivedi, V. and Mitchell, J.C. ORCID: 0000-0003-2945-3292 (2014) Physico-chemical characterization of oral thin film for paediatric buccal drug delivery. In: APS PharmSci 2014, 8-10 Sep 2014, University of Hertfordshire, Hatfield, UK.

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Abstract

Recent changes in regulatory requirements for paediatric formulations demand development of age-appropriate dosage forms that are stable for ease of dosing, compliance and dose flexibility while maintaining accuracy and safety. Films were developed by optimising various formulation variables including type of solvent (water, ethanol), polyethylene glycol (PEG 400) as plasticiser and different film forming polymers [(metolose (MET), hydroxypropylmethylcellulose (HPMC), methylcellulose (MC), sodium alginate (SA), and carrageenan (CA)], drug stabilization and loading capacity. Films were subsequently functionally characterised using various techniques.

Item Type: Conference or Conference Paper (Paper)
Additional Information: [1] Abstract only, published on APS PharmSci 2014 conference website. Paper given at APS PharmSci 2014, held 8-10 September 2014, University of Hertfordshire, Hatfield, UK.
Uncontrolled Keywords: paediatric, films, metolose
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:13
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12410

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