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Abnormalities of the electroretinogram and visual-evoked potential in vitamin E deficient rats

Abnormalities of the electroretinogram and visual-evoked potential in vitamin E deficient rats

Goss-Sampson, M. A., Muller, D. P. and Kriss, A. (1991) Abnormalities of the electroretinogram and visual-evoked potential in vitamin E deficient rats. Experimental eye research, 53 (5). pp. 623-627. ISSN 0014-4835 (Print), 1096-0007 (Online) (doi:10.1016/0014-4835(91)90222-Z)

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Abstract

Flash electroretinograms, retinal oscillatory and cortical visual-evoked potentials were recorded in 10-month vitamin E deficient rats and in age-matched controls. A significant increase in the latency (P less than 0.0001) and decrease in amplitude (P less than 0.0001) of the electroretinogram a- and b-waves were observed in the vitamin E deficient rats compared with controls. The vitamin E deficient rats also showed a significant delay (P less than 0.002) in early oscillatory potentials. No significant group differences were obtained in the P1 latency or P1-N1 amplitude of the visual-evoked potential; however, the N1 peak was significantly delayed (P = 0.01) in the vitamin E deficient rats. This study shows, for the first time, that the electroretinogram and visual-evoked potential to flash stimulation provide a sensitive index for monitoring the visual effects of vitamin E deficiency in the rat.

Item Type: Article
Uncontrolled Keywords: Electroretinogram, Oscillatory potentials, Rat, Visual-evoked potential, Vitamin E deficiency
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 06 Dec 2016 11:23
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12388

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