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Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies.

Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies.

Dexter, D. T., Brooks, D. J., Harding, A. E., Burn, D. J., Muller, D. P., Goss-Sampson, M. A., Jenner, P. G. and Marsden, C. D. (1994) Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies. Annals of neurology, 35 (3). pp. 298-303. ISSN 0364-5134 (Print), 1531-8249 (Online) (doi:10.1002/ana.410350309)

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Abstract

Four patients with vitamin E deficiency and sensory ataxia were studied using [18F]dopa positron emission tomography. The 2 most disabled patients, who had severe and prolonged vitamin E deficiency due to abetalipoproteinemia, showed reduced [18F]dopa uptake in both putamen and caudate. Putaminal uptake was in a similar range to that seen in Parkinson's disease. Studies of [3H]mazindol binding in the striatum of vitamin E--deficient rats indicated a reduced number of dopamine terminals, which was most severe in ventrolateral striatum. These observations suggest that severe and prolonged vitamin E deficiency results in loss of nigrostriatal nerve terminals, and support the hypothesis that oxidative stress may contribute to the etiology of Parkinson's disease.

Item Type: Article
Uncontrolled Keywords: Vitamin E
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 06 Dec 2016 11:02
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12384

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