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Effect of chronic vitamin E deficiency on sympathetic and sensorimotor function in rat mesenteric arteries

Effect of chronic vitamin E deficiency on sympathetic and sensorimotor function in rat mesenteric arteries

Ralevic, V., Hoyle, C. H., Goss-Sampson, M. A., Milla, P. J. and Burnstock, G. (1996) Effect of chronic vitamin E deficiency on sympathetic and sensorimotor function in rat mesenteric arteries. The Journal of Physiology, 490 (1). pp. 181-189. ISSN 0022-3751 (Print), 1469-7793 (Online) (doi:10.1113/jphysiol.1996.sp021134)

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Abstract

1. Mesenteric arterial beds from male rats deprived of vitamin E for 12 months postweaning were isolated and perfused at 5 ml min-1. 2. The basal perfusion pressure of vitamin E-deficient preparations was significantly higher (34.0 +/- 1.9 mmHg, n = 15) than in age-matched controls (26.1 +/- 2 mmHg, n = 14; P < 0.01). 3. At basal tone, vasoconstrictor responses to electrical field stimulation (EFS) were not attenuated by vitamin E deficiency; at high stimulation frequencies, responses were enhanced. According to dose-response curves, exogenous noradrenaline was significantly more efficacious in preparations from vitamin E-deficient rats (P < 0.05). 4. In preparations with tone raised by methoxamine (6-20 microM) and in the presence of guanethidine (5 microM), EFS of perivascular sensorimotor nerves elicited frequency-dependent vasodilatation which was significantly attenuated by vitamin E deficiency. There was no difference in relaxation to calcitonin gene-related peptide (CGRP; 1.5 x 10(-11) mol), or to the sensory neurotoxin capsaicin (5 x 10(-11) mol). 5. Immunohistochemical analysis of CGRP-containing nerves in the superior mesenteric artery showed no differences in density of innervation. 6. In conclusion, chronic vitamin E deficiency impairs sensorimotor vasodilatation in rat mesenteric arteries; this does not appear to be due to changes in postjunctional receptors, or to a depletion of transmitter (CGRP) content of the superior mesenteric artery. Sensorimotor nerves appear to be more vulnerable than sympathetic nerves to chronic vitamin E deficiency.

Item Type: Article
Uncontrolled Keywords: Vitamin E
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 06 Dec 2016 10:52
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12380

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