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Serotonin metabolism and release in frontal cortex of rats on a vitamin E-deficient diet

Serotonin metabolism and release in frontal cortex of rats on a vitamin E-deficient diet

Heslop, K. E., Goss-Sampson, M. A., Muller, D. P. and Curzon, G. (1996) Serotonin metabolism and release in frontal cortex of rats on a vitamin E-deficient diet. Journal of Neurochemistry, 66 (2). pp. 860-864. ISSN 0022-3042 (Print), 1471-4159 (Online) (doi:10.1046/j.1471-4159.1996.66020860.x)

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Abstract

Rats were fed a control or vitamin E (all-rac-alpha-tocopheryl acetate)-deficient diet for 3 or 12 weeks. Serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), tryptophan, and alpha-tocopherol concentrations were determined in the frontal cortex using HPLC, alpha-Tocopherol concentrations fell significantly to 27% of control values at 12 weeks. Tissue 5-HT, 5-HIAA, and tryptophan concentrations were not significantly altered by the vitamin E-deficient diet at either time point. In vivo microdialysis revealed normal basal and K(+)-stimulated concentrations of 5-HT and 5-HIAA, but extracellular concentrations of tryptophan were significantly decreased after 3 weeks on the vitamin E-deficient diet, which resulted in an increase in the tissue/extracellular ratio and suggested a change in compartmentation. However, after 12 weeks on the deficient diet these values had returned to normal. Results in general indicate that a prolonged and substantial depletion of brain vitamin E can occur without major disturbance of serotonergic function.

Item Type: Article
Uncontrolled Keywords: Vitamin E, Frontal cortex, Serotonin, Microdialysis
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Last Modified: 06 Dec 2016 10:39
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/12376

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