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The effect of charge location in ion mobility mass spectrometry for small molecule analytes

The effect of charge location in ion mobility mass spectrometry for small molecule analytes

Lapthorn, Cris, Pullen, Frank, Chowdhry, Babur, Perkins, George, Dines, Trevor and McCullagh, Michael (2014) The effect of charge location in ion mobility mass spectrometry for small molecule analytes. In: 62nd ASMS Conference on Mass Spectrometry and Allied Topics, 15-19 Jun 2014, Baltimore, MD, USA.

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Abstract

In travelling wave IM-MS an electric field is applied across the IMS cell and analyte collisions with the inert gas give rise to a relationship between the drift time and the molecular shape and overall charge.

Recent findings show near baseline IMS separation (R>1) where shape and overall charge appear not to explain the IMS separation. Multiple ion mobility peaks are observed for a single m/z including the fluoroquinolone antibiotics norfloxacin and lomefloxacin, the pesticide indoxacarb and a number of steroids.

Item Type: Conference or Conference Paper (Poster)
Additional Information: [1] Poster WP 695 - presented in Ion Mobility: Fundamentals stream. Part of the 62nd ASMS Conference on Mass Spectrometry and Allied Topics, held 15-19 June 2014, Baltimore Convention Center, Baltimore, MD, USA. [2] British Mass Spectrometry Society, April 2014. Prize awarded for 'The effect of charge location in ion mobility mass spectrometry for small molecule analytes', available at http://dx.doi.org/10.6084/m9.figshare.1134183. Judged by Prof. Graham Cooks (Henry Bohn Hass Distinguished Professor of Chemistry at Purdue University, ISI Highly Cited Chemist with over 950 publications and an H-index of 81) and Prof. Mike Morris (‎Senior Director MS Research at Waters).
Uncontrolled Keywords: charge location, ion mobility mass spectrometry, small molecule analytes
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science
Related URLs:
Last Modified: 14 Oct 2016 09:28
URI: http://gala.gre.ac.uk/id/eprint/12156

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