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Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration

Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration

Hurt, A. P., Getti, G. and Coleman, N.J. (2014) Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration. International Journal of Biological Macromolecules, 64. pp. 11-16. ISSN 0141-8130 (doi:10.1016/j.ijbiomac.2013.11.020)

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Abstract

A polymer-mineral composite membrane of the mucopolysaccharide derivative, chitosan, and calcium silicate hydrate phase, tobermorite, was prepared by solvent casting and characterised by scanning electron microscopy (SEM) and Fourier Transform infrared spectroscopy (FTIR). The bioactivity and biocompatibility of the chitosan-tobermorite composite were evaluated in vitro with respect to its potential for use as a biodegradable guided tissue regeneration (GTR) membrane. The in vitro bioactivity of the composite was confirmed by the formation of crystalline substituted hydroxyapatite on the surface of the embedded tobermorite particles in simulated body fluid. The presence of the composite membrane was found to enhance the growth of MG63 human osteosarcoma cells by up to 30%. The findings of this initial study have indicated that this novel chitosan-tobermorite composite may be a suitable material for GTR applications.

Item Type: Article
Uncontrolled Keywords: chitosan, tobermorite, bioactive
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Life & Sports Sciences
Related URLs:
Last Modified: 04 Dec 2017 10:30
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/11566

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