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Preparation and characterization of novel wound healing film dressings loaded with streptomycin and diclofenac

Preparation and characterization of novel wound healing film dressings loaded with streptomycin and diclofenac

Pawar, H. V., Tetteh, J. and Boateng, J.S. ORCID: 0000-0002-6310-729X (2012) Preparation and characterization of novel wound healing film dressings loaded with streptomycin and diclofenac. Colloids and Surfaces B: Biointerfaces, 102. pp. 102-110. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2012.08.014)

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Abstract

Streptomycin (STP) and diclofenac (DLF) loaded film dressings were prepared by blending Polyox® (POL) with four hydrophilic polymers [hydroxypropylmethylcellulose (HPMC), carrageenan (CAR), sodium alginate (SA) or chitosan (CS)] using glycerol (GLY) as plasticiser. The films were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, texture analysis (tensile and swelling characteristics) and in vitro dissolution profiles using Franz diffusion cell. SEM showed homogeneous morphology for both blank (BLK) and drug loaded (DL) films. Films prepared by blending of POL with the other polymers showed a reduction in the crystallisation of POL in descending order of SA > CS > HPMC > CAR respectively. DSC and XRD showed no crystalline peaks of STP and DLF suggesting molecular dispersion of both drugs as well as possible drug interaction with negatively charged sulphate ions present in CAR. The DL films did not show any IR bands of both drugs, confirming the DSC and XRD results. POL-CAR-BLK films showed higher tensile strength (12.32 ± 1.40 MPa) than the POL-CAR-DL films (9.52 ± 1.12 MPa). DL films plasticized with 25% w/w GLY revealed soft and tough (tensile strength 1.02 ± 0.28 MPa, % elongation 1031.33 ± 16.23) formulations. The swelling capacities of POL-CAR-BLK and POL-CAR-DL films were (733.17 ± 25.78%) and (646.39 ± 40.39%), increasing to (1072.71 ± 80.30%) and (1051 ± 86.68%) for POL-CAR-BLK-25% GLY and POL-CAR-DL-25% GLY respectively. POL-CAR-DL films showed significantly (n=3 p<0.0318) lower cumulative release of STP and DLF (52.11 ± 1.34, 55.26 ± 2.25) compared to POL-CAR-DL-25% GLY films (60.07 ± 1.56, 63.39 ± 1.92) respectively.

Item Type: Article
Uncontrolled Keywords: polymer blend, Polyox®, solvent cast films, wound healing, plasticiser, in vitro drug release
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 06 Dec 2016 15:48
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/10679

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