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Sustained release solid lipid matrices processed by hot-melt extrusion (HME)

Sustained release solid lipid matrices processed by hot-melt extrusion (HME)

Vithani, K., Maniruzzaman, M., Slipper, I.J., Mostafa, S., Miolane, C., Cuppok, Y., Marchaud, D. and Douroumis, D. (2013) Sustained release solid lipid matrices processed by hot-melt extrusion (HME). Colloids and Surfaces B: Biointerfaces, 110. pp. 403-410. ISSN 0927-7765 (doi:10.1016/j.colsurfb.2013.03.060)

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Abstract

The aim of this work was to develop sustained release solid lipid matrices of diclofenac sodium (Df-Na) processed by hot melt extrusion (HME) and subsequent compression into tablets. Different extrusion processing approaches such as “cold”, “hot” and pre-mixed formulations were used to develop the Compritol® 888 ATO lipid matrices by altering the extrusion temperatures, drug loading and formulation composition. The extrudates were characterized via a range of techniques such as differential scanning calorimetry (DSC), hot stage microscopy (HSM) and X-ray powder diffraction (XRPD) to identify the drug state within the lipid matrix. Df-Na was found to be either in crystalline or amorphous state depending on the processing conditions. Energy dispersive X-ray (EDX) microanalysis demonstrated excellent drug distribution of Df-Na on the surface of the compressed tablets. The lipid matrices developed by HME provided sustained release of pre-mixed formulations for 12 h mainly controlled by diffusion.

Item Type: Article
Additional Information: [1] First published online: 18 May 2013. [2] Published in print: 1 October 2013.
Uncontrolled Keywords: extrusion, lipids, solid dispersions, tablet, solid dosage form
Subjects: Q Science > QD Chemistry
Faculty / Department / Research Group: Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 06 Dec 2016 14:22
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/10640

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