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Melting behaviour of triblock polymers (poloxamers) in supercritical CO2

Melting behaviour of triblock polymers (poloxamers) in supercritical CO2

Trivedi, Vivek, Bhomia, Ruchir, Coleman, Nichola and Mitchell, John (2013) Melting behaviour of triblock polymers (poloxamers) in supercritical CO2. In: 6th INTERNATIONAL SYMPOSIUM ON HIGH PRESSURE PROCESSES TECHNOLOGY, 8-11 SEP 2013, Belgrade, Serbia. (Unpublished)

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Abstract

Carbon dioxide (CO2) is the most commonly used SCF because of the relatively mild operating conditions (31.1°C and 72.8 bar) and easily tuneable properties. Moreover, the ability of CO2 to act as a solvent and solute has made it highly desirable in the field of excipient processing, particle formation and drug encapsulation. The dissolution of CO2 is known to affect glass transition or melting temperature of polymers and fats [1]. In this work, the effect of the dissolution of liquid (l.CO2) or supercritical (sc. CO2) was studied on the melting point of various poloxamers (Pluronic™ F77, F127, F38, F68, F108) at the pressure ranging from 70 to 250 bar in a supercritical phase monitor. The treated and untreated samples were analysed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC).

Item Type: Conference or Conference Paper (Lecture)
Uncontrolled Keywords: Supercritical CO2. Melting. Triblock polymer. Poloxamers
Subjects: Q Science > Q Science (General)
T Technology > T Technology (General)
Faculty / Department / Research Group: Faculty of Engineering & Science
Faculty of Engineering & Science > Department of Pharmaceutical, Chemical & Environmental Sciences
Related URLs:
Last Modified: 17 Oct 2016 09:12
Selected for GREAT 2016: None
Selected for GREAT 2017: None
Selected for GREAT 2018: None
URI: http://gala.gre.ac.uk/id/eprint/10584

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